刘丽梅

学术任职

中华医学会医学遗传学会委员、国家卫计委临床遗传专科委员会秘书长；上海医学会医学遗传学会副主任委员、上海遗传学会理事、上海内分泌学会委员、中华医学会糖尿病微血管学组委员、Journal of Diabetes Investigation、Mol Cell Biochem通讯编委、中国糖尿病杂志编委。

学术贡献

精通两门外语（英、日语）。主要从事儿童、青少年特殊类型糖尿病（MODY、线粒体糖尿病等）、2型糖尿病以及糖尿病肾病的分子遗传机制、基因诊断与精准治疗研究。以第一负责人承担多项国家自然科学基金。2013年率先世界发现“首个中国MODY基因”、2010年率先发现PPARG基因Pro12Ala突变与吸烟相互作用促发糖尿病肾病（DN）机制，其假说被后续高加索人群研究所证实，Diabetes Care杂志撰文予以高度评价。以第一、通讯作者在Diabetes Care、Diabetologia、Mol Cell Biochemistry等杂志发表论文60余篇，共同主编《糖尿病肾病》、参编《特殊类型糖尿病》、《临床遗传学》。

荣获“国家科技进步二等奖”、“上海市科技进步三等奖”、“上海领军人才”、“上海市优秀学科带头人”、“中国糖尿病十大研究最具影响力研究奖”、“国际糖尿病十大热点第一名”、美国71th糖尿病年会（ADA）大会专题报告发言-荣誉证书、科学中国人（2014）年度人物等。

文献发表

Zhuang L, Zhao Y, Zhao W, Li M, Yu M, Lu M, Zhang R, Ge X, Zheng T, Li C, Yin J, Yin J, Bao Y, Liu L, Jia W, Liu Y. The E23K and A190A variations of the KCNJ11 gene are associated with early-onset type 2 diabetes and blood pressure in the Chinese population. Mol Cell Biochem. 2015 Jun;404(1-2):133-41.

Wang Y, Yan C, Liu L, Wang W, Du H, Fan W, Lutfy K, Jiang M, Friedman TC, Liu Y. 11β-Hydroxysteroid dehydrogenase type 1 shRNA ameliorates glucocorticoid-induced insulin resistance and lipolysis in mouse abdominal adipose tissue. Am J Physiol Endocrinol Metab. 2015 Jan 1;308(1):E84-95.

Hong Chen*, Ming Yu, Ming Li, Ruie Zhao,Wenrui Zhou, Ming Lu, Yufeng Lu, Taishan Zheng, Jiamei Jiang, Weijing Zhao, Kunsan Xiang, Weiping Jia and Limei Liu#. Polymorphic Variations in Manganese Superoxide Dismutase (MnSOD), Glutathione Peroxidase-1 (GPX1) and Catalase (CAT) Contribute to Elevated Plasma Triglyceride Levels in Chinese Patients with Type 2 Diabetes or Diabetic Cardiovascular Disease. Mol Cell Biochem,2012;363:85-91.

Limei Liu*#, Taishan Zheng, Feng Wang, Niansong Wang, Yanyan Song, Ming Li, Lifang Li, Jiamei Jiang, Weijing Zhao.. Pro12Ala polymorphism in the PPARG gene contributes to the development of diabetic nephropathy in Chinese type 2 diabetes. . Diabetes Care,2010;33(1):144-149.

Limei Liu, Taishan Zheng, Feng Wang, Niansong Wang and Ming Li. Pro12Ala polymorphism in the PPARG gene contributes to the development of diabetic nephropathy in Chinese type 2 diabetic patients: Response to Lapice et al.. Diabetes Care,2010;33(8):e115.

Limei Liu, Taishan Zheng, Niansong Wang, Feng Wang, Ming Li, Jiamei Jiang, Ruie Zhao, Lifang Li, Weijing Zhao, Qihan Zhu, Weiping Jia. The manganese superoxide dismutase Val16Ala polymorphism is associated with decreased risk of diabetic nephropathy in Chinese patients with type diabetes. Mol Cell Biochem,2009;22:87-91.

Limei Liu, Hiroto Furuta Asako Minami Taishan Zheng Weiping Jia Kishio Nanjo Kunsan Xiang. A novel mutation, Ser159Pro in the NeuroD1/BETA2gene contributes to the development of diabetes in a Chinese potential MODY family. Mol Cell Biochem,2007;303:115-120.

Limei Liu, Weiping Jia, Taishan Zheng, Ming Li, Huijuan Lu and Kunsan Xiang. Ala45Thr variation in neuroD1 gene is associated with early-onset type 2 diabetes with or without diabetic pedigree in Chinese. Mol Cell Biochem,2006;290:199-204